Assistant Professor of Pathology, Assistant Professor of Radiation Oncology
Primary Office: 1020 Medical Laboratories
Iowa City, IA 52242


BS, Microbiology, Nankai University, Tianjin, China
MS, Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
PhD, Microbiology, Mount Sinai School of Medicine, New York University, NY

Post Doctorate, Fellow, Mount Sinai School of Medicine, New York School of Medicine
Post Doctorate, Fellow, Pharmacology, University of California, San Diego

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Molecular and Cellular Biology

Research Summary

Role of inflammation in breast cancer initiation, progression and metastasis.

Selected Publications

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Tan W, Zhang W, Strasner A, Grivennikov S, Cheng J, Hoffman R, Karin M.  Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling.  Nature.  2011. 470(7335):548-53. 

Zhang W, Kater A, Widhopf G, Chuang H, Enzler T, James D, Poustovoitov M, Tseng P, Janz S, Hoh C, Herschman H, Karin M, Kipps T.  B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia.  Proceedings of the National Academy of Sciences of the United States of America.  2010. 107(44):18956-60. 

Tseng P, Matsuzawa A, Zhang W, Mino T, Vignali D, Karin M.  Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines.  Nature immunology.  2010. 11(1):70-5. 

Enzler T, Kater A, Zhang W, Widhopf G, Chuang H, Lee J, Avery E, Croce C, Karin M, Kipps T.  Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression.  Blood.  2009. 114(20):4469-76. 

Cheng G, Park S, Shu S, He L, Kong W, Zhang W, Yuan Z, Wang L, Cheng J.  Advances of AKT pathway in human oncogenesis and as a target for anti-cancer drug discovery.  Current cancer drug targets.  2008. 8(1):2-6. 

Matsuzawa A, Tseng P, Vallabhapurapu S, Luo J, Zhang W, Wang H, Vignali D, Gallagher E, Karin M.  Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex.  Science.  2008. 321(5889):663-8. 

Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng P, Keats J, Wang H, Vignali D, Bergsagel P, Karin M.  Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling.  Nature immunology.  2008. 9(12):1364-70. 

Zhang W, Cheng G, Gong J, Hermanto U, Zong C, Chan J, Cheng J, Wang L.  RACK1 and CIS mediate the degradation of BimEL in cancer cells.  The Journal of biological chemistry.  2008. 283(24):16416-26. 

Cheng G, Zhang W, Wang L.  Regulation of cancer cell survival, migration, and invasion by Twist: AKT2 comes to interplay.  Cancer research.  2008. 68(4):957-60. 

Masker K, Golden A, Gaffney C, Mazack V, Schwindinger W, Zhang W, Wang L, Carey D, Sudol M.  Transcriptional profile of Rous Sarcoma Virus transformed chicken embryo fibroblasts reveals new signaling targets of viral-src.  Virology.  2007. 364(1):10-20.